Transcription factor activator protein 2C and downstream redox biology effectors in development and carcinogenesis
نویسندگان
چکیده
Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date
منابع مشابه
Transcription Factors as Targets for Cancer Therapy: AP-1 a Potential Therapeutic Target
The field of cancer therapy is rapidly moving forward with the development of numerous prospective new agents designed to inhibit cellular factors involved in signal transduction, cell proliferation, and the onset of apoptosis. At the core of these biological processes are transcription factors that are the functional mediators of these effects. Transcription factors are the downstream targets ...
متن کاملKidney Cell Tumorigenesis Counterbalancing Isoform Coactivator Modulator in Human Dual Roles for Coactivator Activator and its
Coactivator activator (CoAA) has been reported to be a coactivator that regulates steroid receptor–mediated transcription and alternative RNA splicing. Herein, we show that CoAA is a dual-function coregulator that inhibits G1-S transition in human kidney cells and suppresses anchorageindependent growth and xenograft tumor formation. Suppression occurs in part by down-regulating c-myc and its do...
متن کاملThe enhancing effect of electromagnetic field on the expression of Oligodendrocyte transcription factor 1 and 2 (Olig1/2) in the mice cerebral cortex
Olig1 and Olig2, two transcription factors, play regulatory function in the differentiation and specification of oligodendrocyte progenitor cells (OPCs). In this study the effects of electromagnetic fields (EMF) on total protein concentration ( TPC ) and Olig1 and Olig2 expression in the cerebral cortex of mouse was examined. Twenty-one Balb/c mice were separated into three groups: control, EMF...
متن کاملReceptor activator for nuclear factor-jB ligand signaling promotes progesterone-mediated estrogen-induced mammary carcinogenesis
doi: 10.1111/cas.12571 Breast cancer is a leading cause of cancer-related death in women. Prolonged exposure to the ovarian hormones estrogen and progesterone increases the risk of breast cancer. Although estrogen is known as a primary factor in mammary carcinogenesis, very few studies have investigated the role of progesterone. Receptor activator for nuclear factor-jB (NF-jB) ligand (RANKL) pl...
متن کاملLipid Rafts and Caveolin-1 Coordinate Interleukin-1 (IL-1 )-dependent Activation of NF B by Controlling Endocytosis of Nox2 and IL-1 Receptor 1 from the Plasma Membrane*
Recent evidence suggests that signaling by the proinflammatory cytokine interleukin-1 (IL-1 ) is dependent on reactive oxygen species derived from NADPH oxidase. Redox signaling in response to IL-1 is known to require endocytosis of its cognate receptor (IL-1R1) following ligand binding and the formation of redox-active signaling endosomes that contain Nox2 (also called redoxosomes). The conseq...
متن کامل